Our research has 4 main themes:
1. Clinical Intervention Trials: We conduct Randomized Controlled Trials (RCTs) of strategies for people with tendinopathy, such as topical diclofenac, intratendinous injections like platelet-rich plasma (PRP), or intramuscular stimulation (IMS).
2. Laboratory and Cellular Studies: We investigate tendon pathology, often involving human tenocyte cell cultures subjected to mechanical stimulation. This includes investigations into inflammatory mechanisms, such as the role of mast cells and substance P, and the effects of hypercholesterolemia (e.g., exposure to oxidized LDL). The program also uses animal models to study tendon injury, degeneration, and repair.
3. Biomechanical, Imaging, and Validation Studies: We are assessing and validating objective measurement tools, such as the use of a bluetooth-enabled load cell for lower extremity strength assessment and telerehabilitation. Imaging techniques, including Dixon method MRI and ultrasound tissue characterization (UTC), are used to assess tendon structure and lipid content, alongside measuring dynamic and tensile tendon stiffness and biomechanical parameters.
4. Epidemiological and Knowledge Synthesis Methods: We synthesize existing data and understanding in clinical practice, including systematic reviews and scoping reviews and Delphi consensus studies with international experts and patients to establish standardized outcomes or definitions.